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Oakes, Scott
One or more keywords matched the following properties of Oakes, Scott
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keywords Endoplasmic Reticulum Stress
overview Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.
One or more keywords matched the following items that are connected to Oakes, Scott
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Concept Endoplasmic Reticulum
Academic Article Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Academic Article Untangling the web: mitochondrial fission and apoptosis.
Academic Article IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Academic Article IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Academic Article BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Academic Article The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.
Academic Article IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
Academic Article Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
Academic Article The role of endoplasmic reticulum stress in human pathology.
Academic Article Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Academic Article Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
Academic Article Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.
Academic Article A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
Academic Article Signaling cell death from the endoplasmic reticulum stress response.
Academic Article Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress.
Academic Article CPEB4 links the clock and the UPR to protect the liver.
Academic Article Endoplasmic reticulum proteostasis: a key checkpoint in cancer.
Academic Article The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article Proteostasis control by the unfolded protein response.
Grant BAX/BAK control ER-mitochondria apoptotic crosstalk
Grant Signaling Cell Death from the Endoplasmic Reticulum
Grant Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
Academic Article Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Academic Article Endoplasmic Reticulum Stress Signaling in Cancer Cells.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Academic Article Deletion of the Unfolded Protein Response Transducer IRE1a Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.
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  • Endoplasmic Reticulum